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Lactobacillus & related genera

Most do not settle long term. They interact with the resident microbes as they pass through, and effects depend on the specific strain.

Full ranking Dose tool Products (460)

Key facts

Daily Value (US FDA)—
Tolerable Upper Intake Level (UL)—
Median (Per day)690,000,000 CFUP5 20,000,000 – P95 10,000,000,000
Products460

No authoritative upper value was found. Bounds used to screen out obvious label errors are estimated from the label distribution; see the Methodology.

How it works: Do probiotics stay in the gut for good?

Do probiotics stay in the gut for good? Live microbes (CFU) Survive stomach acid Gut microbiota Host interaction
1/4Probiotics are live microorganisms; labels give the count in CFU (colony-forming units). The count at expiry may be lower than at manufacture.
  1. Probiotics are live microorganisms; labels give the count in CFU (colony-forming units). The count at expiry may be lower than at manufacture.
  2. Some microbes die passing through stomach acid and bile.
  3. Survivors interact with the resident gut microbes; most do not colonise long term.
  4. Possible modes of action include making short-chain fatty acids, competing with pathogens and influencing immune responses; strains differ widely.

Schematic only; positions and scale are not anatomical.

Limits and cautions: Effects are strain-specific; results for one strain cannot be applied to another. People with severely weakened immune systems should ask a doctor first.

Sources: NIH ODS: Probiotics Fact Sheet for Health Professionals

Daily dose across products (CFU/day)

3,750,000 CFUlog scale · n=460100,000,000,000 CFU

Label data from official national databases and brand websites, as declared; not lab-verified.

Common questions

What are the side effects of Lactobacillus & related genera?

Probiotics have a long history of apparently safe use in healthy people, but few studies look at safety in detail. Possible harms include infections, harmful substances made by the microbes, and transfer of antibiotic-resistance genes. Some products contained microbes not on the label. (Source: NIH NCCIH) [source]

What happens if you take too much Lactobacillus & related genera?

The risk is higher for people who are seriously ill or immunocompromised. The FDA has warned that premature infants given probiotics have had severe, sometimes fatal infections. (Source: NIH NCCIH) [source]

Does Lactobacillus & related genera interact with medications or other supplements?

Different strains act differently: one Lactobacillus helping does not mean another, or a Bifidobacterium, will. People with health problems should ask a provider first and not use probiotics as a reason to delay care. (Source: NIH NCCIH) [source]

Top ranked

RankBrandProductPer dayScore
1Biena Inc.Probiotic GG 10B10,000,000,000 CFU93.3
1Biena Inc.Probiotic GG 6B6,000,000,000 CFU93.3
1Biena Inc.Probiotic Lactobacillus rhamnosus GG 10B10,000,000,000 CFU93.3
1Biena Inc.Probiotic with Lactobacillus rhamnosus GG 5B5,000,000,000 CFU93.3
5Country Life LLCAcidophilus1,200,000,000 CFU87.8

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For information only; not medical advice. Talk to a doctor or pharmacist before starting or stopping any supplement.
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